Short-term, daily intake of yogurt containing Bifidobacterium animalis ssp. lactis Bf-6 (LMG 24384) does not affect colonic transit time in women.
Identifieur interne : 001343 ( Main/Exploration ); précédent : 001342; suivant : 001344Short-term, daily intake of yogurt containing Bifidobacterium animalis ssp. lactis Bf-6 (LMG 24384) does not affect colonic transit time in women.
Auteurs : Daniel J. Merenstein [États-Unis] ; Frank D'Amico [États-Unis] ; Caren Palese [États-Unis] ; Alexander Hahn [États-Unis] ; Jessy Sparenborg [États-Unis] ; Tina Tan [États-Unis] ; Hillary Scott [États-Unis] ; Kayla Polzin [États-Unis] ; Lore Kolberg [États-Unis] ; Robert Roberts [États-Unis]Source :
- The British journal of nutrition [ 1475-2662 ] ; 2014.
Descripteurs français
- KwdFr :
- MESH :
- microbiologie : Yaourt.
- physiologie : Bifidobacterium, Côlon, Transit gastrointestinal.
- Adolescent, Adulte, Femelle, Humains, Jeune adulte, Probiotiques, Études croisées.
English descriptors
- KwdEn :
- MESH :
- microbiology : Yogurt.
- physiology : Bifidobacterium, Colon, Gastrointestinal Transit.
- Adolescent, Adult, Cross-Over Studies, Female, Humans, Probiotics, Young Adult.
Abstract
The present study investigated the effect of Bifidobacterium animalis ssp. lactis Bf-6 (LMG 24 384) (Bf-6)-supplemented yogurt on colonic transit time (CTT). A triple-blinded, randomised, placebo-controlled, two-period cross-over trial was conducted with sixty-eight women with a self-reported history of straining during bowel movements or hard or lumpy stools in the past 2 years. As per regulatory requirements for probiotic studies, eligible women were generally healthy and not actively constipated at the time of enrolment. Participants consumed both Bf-6 and placebo yogurts for 14 d each in a randomised order, with a 6-week washout period between the treatments. The primary outcome, CTT, was assessed via Sitz marker X-rays. The average CTT was 42·1 h for the active period and 43·3 h for the control period (mean difference 1·2 h, 95 % CI - 4·9, 7·4). Since the statistical tests for the cross-over study implied that the mean CTT for the active and control periods in period 2 were biased, the standard protocol suggests examining the results of only period 1 as a traditional randomised controlled trial. This showed that the mean CTT was 35·2 h for the active period v. 52·9 h for the control period (P= 0·015). Bootstrapping demonstrated that both the mean and median differences remained significant (P= 0·016 and P= 0·045, respectively). Few adverse events were noted, with no differences among the active and control periods. The paired analysis showed no differences between the active and control periods during the cross-over trial. Further trials should be conducted in populations with underlying problems associated with disordered transit to determine the potential value of probiotic supplementation more accurately.
DOI: 10.1017/S0007114513002237
PubMed: 24103188
Affiliations:
- États-Unis
- District de Columbia, Minnesota, Pennsylvanie
- University Park (Pennsylvanie)
- Université d'État de Pennsylvanie
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Le document en format XML
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women.</title><author><name sortKey="Merenstein, Daniel J" sort="Merenstein, Daniel J" uniqKey="Merenstein D" first="Daniel J" last="Merenstein">Daniel J. Merenstein</name><affiliation wicri:level="2"><nlm:affiliation>Department of Family Medicine, Georgetown University Medical Center, 240 Building D, 4000 Reservoir Road NW, Washington, DC 20007-2145, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Family Medicine, Georgetown University Medical Center, 240 Building D, 4000 Reservoir Road NW, Washington, DC 20007-2145</wicri:regionArea><placeName><region type="state">District de Columbia</region></placeName></affiliation></author><author><name sortKey="D Amico, Frank" sort="D Amico, Frank" uniqKey="D Amico F" first="Frank" last="D'Amico">Frank D'Amico</name><affiliation wicri:level="2"><nlm:affiliation>Department of Mathematics, UPMC, St. Margaret Hospital, Duquesne University, Pittsburgh, PA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Mathematics, UPMC, St. Margaret Hospital, Duquesne University, Pittsburgh, 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Columbia</region></placeName></affiliation></author><author><name sortKey="Tan, Tina" sort="Tan, Tina" uniqKey="Tan T" first="Tina" last="Tan">Tina Tan</name><affiliation wicri:level="2"><nlm:affiliation>Department of Family Medicine, Georgetown University Medical Center, 240 Building D, 4000 Reservoir Road NW, Washington, DC 20007-2145, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Family Medicine, Georgetown University Medical Center, 240 Building D, 4000 Reservoir Road NW, Washington, DC 20007-2145</wicri:regionArea><placeName><region type="state">District de Columbia</region></placeName></affiliation></author><author><name sortKey="Scott, Hillary" sort="Scott, Hillary" uniqKey="Scott H" first="Hillary" last="Scott">Hillary Scott</name><affiliation wicri:level="2"><nlm:affiliation>Division of Gastroenterology, Department of Medicine, Georgetown University Medical Center, Washington, DC, USA.</nlm:affiliation><country 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MN</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Roberts, Robert" sort="Roberts, Robert" uniqKey="Roberts R" first="Robert" last="Roberts">Robert Roberts</name><affiliation wicri:level="4"><nlm:affiliation>Department of Food Science, The Pennsylvania State University, University Park, PA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Food Science, The Pennsylvania State University, University Park, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">University Park (Pennsylvanie)</settlement></placeName><orgName type="university">Université d'État de Pennsylvanie</orgName></affiliation></author></analytic><series><title level="j">The British journal of nutrition</title><idno type="eISSN">1475-2662</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Bifidobacterium (physiology)</term><term>Colon (physiology)</term><term>Cross-Over Studies</term><term>Female</term><term>Gastrointestinal Transit (physiology)</term><term>Humans</term><term>Probiotics</term><term>Yogurt (microbiology)</term><term>Young Adult</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Bifidobacterium (physiologie)</term><term>Côlon (physiologie)</term><term>Femelle</term><term>Humains</term><term>Jeune adulte</term><term>Probiotiques</term><term>Transit gastrointestinal (physiologie)</term><term>Yaourt (microbiologie)</term><term>Études croisées</term></keywords><keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Yaourt</term></keywords><keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Yogurt</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Bifidobacterium</term><term>Côlon</term><term>Transit gastrointestinal</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Bifidobacterium</term><term>Colon</term><term>Gastrointestinal Transit</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Cross-Over Studies</term><term>Female</term><term>Humans</term><term>Probiotics</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Femelle</term><term>Humains</term><term>Jeune adulte</term><term>Probiotiques</term><term>Études croisées</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The present study investigated the effect of Bifidobacterium animalis ssp. lactis Bf-6 (LMG 24 384) (Bf-6)-supplemented yogurt on colonic transit time (CTT). A triple-blinded, randomised, placebo-controlled, two-period cross-over trial was conducted with sixty-eight women with a self-reported history of straining during bowel movements or hard or lumpy stools in the past 2 years. As per regulatory requirements for probiotic studies, eligible women were generally healthy and not actively constipated at the time of enrolment. Participants consumed both Bf-6 and placebo yogurts for 14 d each in a randomised order, with a 6-week washout period between the treatments. The primary outcome, CTT, was assessed via Sitz marker X-rays. The average CTT was 42·1 h for the active period and 43·3 h for the control period (mean difference 1·2 h, 95 % CI - 4·9, 7·4). Since the statistical tests for the cross-over study implied that the mean CTT for the active and control periods in period 2 were biased, the standard protocol suggests examining the results of only period 1 as a traditional randomised controlled trial. This showed that the mean CTT was 35·2 h for the active period v. 52·9 h for the control period (P= 0·015). Bootstrapping demonstrated that both the mean and median differences remained significant (P= 0·016 and P= 0·045, respectively). Few adverse events were noted, with no differences among the active and control periods. The paired analysis showed no differences between the active and control periods during the cross-over trial. Further trials should be conducted in populations with underlying problems associated with disordered transit to determine the potential value of probiotic supplementation more accurately.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>District de Columbia</li><li>Minnesota</li><li>Pennsylvanie</li></region><settlement><li>University Park (Pennsylvanie)</li></settlement><orgName><li>Université d'État de Pennsylvanie</li></orgName></list><tree><country name="États-Unis"><region name="District de Columbia"><name sortKey="Merenstein, Daniel J" sort="Merenstein, Daniel J" uniqKey="Merenstein D" first="Daniel J" last="Merenstein">Daniel J. Merenstein</name></region><name sortKey="D Amico, Frank" sort="D Amico, Frank" uniqKey="D Amico F" first="Frank" last="D'Amico">Frank D'Amico</name><name sortKey="Hahn, Alexander" sort="Hahn, Alexander" uniqKey="Hahn A" first="Alexander" last="Hahn">Alexander Hahn</name><name sortKey="Kolberg, Lore" sort="Kolberg, Lore" uniqKey="Kolberg L" first="Lore" last="Kolberg">Lore Kolberg</name><name sortKey="Palese, Caren" sort="Palese, Caren" uniqKey="Palese C" first="Caren" last="Palese">Caren Palese</name><name sortKey="Polzin, Kayla" sort="Polzin, Kayla" uniqKey="Polzin K" first="Kayla" last="Polzin">Kayla Polzin</name><name sortKey="Roberts, Robert" sort="Roberts, Robert" uniqKey="Roberts R" first="Robert" last="Roberts">Robert Roberts</name><name sortKey="Scott, Hillary" sort="Scott, Hillary" uniqKey="Scott H" first="Hillary" last="Scott">Hillary Scott</name><name sortKey="Sparenborg, Jessy" sort="Sparenborg, Jessy" uniqKey="Sparenborg J" first="Jessy" last="Sparenborg">Jessy Sparenborg</name><name sortKey="Tan, Tina" sort="Tan, Tina" uniqKey="Tan T" first="Tina" last="Tan">Tina Tan</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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